• 8 days ago

    Severe muscle cramps on methotrexate or azathioprine

    My partner has been treated for sarcoidosis for the past 4 years.
    They started his treatment with prednisone and methotrexate. He suffered severe muscle cramps all over his body. He pulled the pin on his treatment after about 8 months because he was exhausted from lack of sleep and couldn’t handle the pain anymore. He takes magnesium and potassium supplements which don’t change a thing. He started on azathioprine and Prednisone and suffered the same side effects. What we did find in his case is that by taking the prednisone in the morning and the methotrexate or azathioprine 12 hours later the cramps seemed to reduce to tolerable level. I’m posting this to help people that may have the same problem. I know I scoured the net looking for answers and the only advise I could find was eat a banana.