• over 1 year ago

    Wellbutrin/Bupropion Ghost Pills

    Are Bupropion/Wellbutrin 300 mg XL extended release shells supposed to be empty when they are passed, or are they supposed to be full of a white powdery substance?

    I was taking Bupropion HCL XL 300mg and passing full tablets. I suffer from IBS-D and also take Nexium acid reducer, either of which might be causing the pills to pass before the medication is absorbed. My depression was not improving while taking this dosage for 5 months, but it had previously improved immediately when I initially began taking 150mg dosage (which do not have the same casing that the 300mg do).

    I recently switched back to 150mg, taking twice daily now, and my depression symptoms started improving again within 24 hours. I have researched this matter extensively but have not been able to get a definitive answer to this question.

Responses

  • over 1 year ago

    RE: Wellbutrin/Bupropion Ghost Pills

    Have you asked your doctor?
      • over 1 year ago
        Yes, I have asked doctors and pharmacists, none of which knew the answer or even that an undissolved shell would pass. The pharmaceutical company finally called me back after I had posted this question. The shells are supposed to be empty when passed. They asked me a lot of questions, got the contact info for my doctors and pharmacist, and will be taking a serious look into this matter.

        I strongly urge anyone with this issue to keep pushing for a definitive answer and contact the manufacturer of the medication if necessary. From what I’ve seen posted on various forums, there are many out there who are not getting any or all of their prescribed medication. I wasted 5 months spiraling deeper into depression before finding this out. Don’t blindly trust the medical industry and do your own research.

        Switching to 150mg twice daily continues to create dramatic improvement, even within the first week.
  • over 1 year ago

    RE: Wellbutrin/Bupropion Ghost Pills

    Please talk to your doctor or pharmacists if you believe the form of this medication you are taking is not effect. The capsules should complete resolve in water if not stomach acids so if you are passing in tact capsules empty or full, something is wrong. Most medications can be requested in tablet, liquid or even sprinkle formats. Your pharmacist should know if an alternative can be requested, if not explain the problem with your doctor to receive appropriate forms and dosage to help treat your illness.
      • over 1 year ago
        Thank you for your recommendations. However, it is common in medications such as Bupropion XL have an insoluble shell that does not dissolve and is passed in the stool and is referred to as a "ghost tablet." The product insert explains this but it states that "This is normal, as it is the empty shell passing from the body." Mine were not passing empty but full.

        Two possible reasons mine were not releasing the drug before passing are IBS-D (causing the drug to pass too quickly) and/or acid reducer to treat acid reflux meant my stomach acids were not adequate for the capsules to perform properly.

        Problem is solved for me by switching to a different form of tablet. But there are others who have experienced this same issue according to many posts I have seen. Neither my doctor, my pharmacist or the pharmaceutical company knew as much as I have learned on this subject. So my advice is to do some research and not rely solely on our medical system.
  • 10 days ago

    RE: Wellbutrin/Bupropion Ghost Pills

    I know this post is old, but do you mind sharing the manufacturer of the buproprion generic that did this? It happened to me as well (took a generic, saw it was mostly undissolved in my stool, had depression symptoms return), and I am kicking myself for not bringing it up to my doctor or noting what manufacturer it was.