• 7 months ago

    Glucagon-like peptide-1 analogues for type 2 diabetes

    A 58 year old woman attends a diabetes clinic with type 2 diabetes of seven years’ duration and no history of macrovascular disease. She is obese (body mass index 37), but says she eats a healthy diet and describes this. Her blood pressure is 134/78 mm Hg, and she has microalbuminuria, but normal renal function and a lipid profile within target levels ranges. She is taking simvastatin 40 mg daily and perindopril 4 mg daily. Glycated haemoglobin (HbA1c) is 8.3% despite treatment with metformin 850 mg three times a day and gliclazide 160 mg twice a day. How would you best manage her hyperglycaemia? (The table⇓ shows the drug treatment options.)

    After discussion with the patient of the benefits and risks of the available treatment options (including the “do nothing” option, risks of hypoglycaemia, and effects on body weight), you agree on a glucagon-like peptide-1 (GLP-1) analogue (exenatide or liraglutide). Visit https://www.creative-peptides.com/research-areas/peptides-in-diabetes.html to know more about Glucagon-like peptides.

Responses

  • 7 months ago

    RE: Glucagon-like peptide-1 analogues for type 2 diabetes

    "...She is obese (body mass index 37), but says she eats a healthy diet and describes this..."

    Well, if she says, so...
    ...but, the human body don't lie!


    My mom is 95. She takes no meds. She has no joint pain, walks in balance & stability, vitals are, all, normal. Though she no longer maintains a regular, daily exercise program, she has maintained a weight of 105 lbs, +/- 3 to 4 lbs, for the last 20 years.

    She, too, eats a "healthy" diet.

    My point is: A true "healthy" diet builds a foundation for stability. The human body seeks to maintain homeostasis. It does not want to gain weight. It does not wish for rising blood pressure or blood sugar or dislipidemia. Its does not want to develop malignant tumors or auto-immune conditions like hashimoto's thyroiditis or rheumatoid arthritis or pernicious anemia...

    If vitals are changing, this means the body is NOT in a balanced state...it's, actually, in turmoil! It suggests that "inflammation" is taking place in multiple areas of the body. This is not "healthy". This is, in fact, "unhealthy". That's about as common sense simple as I can put it.


    My recommendation to any person suffering from any lifestyle disease, before you start dosing (or, shall I say, "dousing") your body with prescription drugs (that really have no natural business being in your body from the get-go), you need to establish a baseline, daily lifestyle process that yields some semblance of stability and consistency. Exercise, diet, water consumption, sleep, relaxation are, all, necessary factors for stable health and fitness.

    And, the very first place you start is with diet! A healthy diet does not make things worse! You do not gain weight & become obese by eating a healthy diet. Nobody in the history of history has gotten big eating apples, spinach, sweet potato or green onions on a routine basis.

    In truth, a healthy diet can not only provide homeostasis & balance, but, in my case, it help me to "reverse" my obesity and Type 2 Diabetes. I've not A1c tested higher than 5.5 in the last 12 years by eating a "healthy" diet.


    This is a perfect example of how the medical community "treats" diseases like T2 diabetes: Take the patient's word about leading a "healthy" lifestyle, then, throw drugs (and, $$$) at the problem. This is the extent of our exploration and investigation into root cause analysis of T2D.

    Intelligent and highly educated adults, here, never ask the questions,

    1. Why does T2D tend to develop after age 40?, and
    2. Why do blood sugar, triglycerides, blood pressure, HDL, all, seem to magically "normalize" with weight loss?

    My body "treated" my T2 diabetes (just as it had the first 50 years of my life!). The only thing I did was be far more diligent and discriminating in the "stuff" I put in it. Now, that I've experienced Type 2 Diabetes Reversal, I realize that as long as I eat a "healthy" diet, my body will do all the heavy lifting, required.

    Think, if "treatment" of T2D by drugs was viable and effective, wouldn't that be the most important, the most ground-breaking medical discovery since penicillin.

    If treatment of T2D was reality, don't you think Youtube & Google would share this with us, by, now?
      • 7 months ago
        https://messageboards.webmd.com/health-conditions/f/diabetes/89415/thoughts-to-remind-all-of-us
        (posted on 04-16-2019)

        I would have no problems with treating diabetes with drugs, with one caveat. Show me one drug that heals or reverses diabetes?

        The problem is, lifestyle can cause injury. Like it did for me. And, like its doing to her.

        How do I know this?

        Because, how do you explain all the decades prior to now, that she didn't have hyperglycemia? Why is this happening, now?

        Simple. Our lifestyle injured us, slowly, methodically, imperceptibly, over time. She's obese (as was, I) is she, not?

        Smoking can injure.
        Alcohol can injure.
        Too much red meat can injure.
        Sleep apnea can injure.
        Nocturia can injure.
        Frozen dinners can injure.
        Condiments and salad dressings can injure.
        Ice cream can injure.
        Four cups of coffee with cream and sugar can injure.
        A hellacious employer can injure.
        Hellacious family members can most definitely injure.
        Too much ibuprofen and acetaminophen can injure.
        Talcum powder can injure.
        (There's several hundred more examples upon request, only...)

        Watch this ridiculous commercial, for example. (the drug may be god's gift, I don't know, I'm just referring to the asinine commercial, itself).

        https://www.ispot.tv/ad/IymV/jardiance-jardiance-asks-thinking-about-your-heart

        Listen, closely, at 0:30 to 0:35:

        Patient: "It lowers A1C?"
        Drug Man: "Yeah...with diet & exercise."

        hahaha...Yeah, eating a proper diet and exercising 30 minutes, daily might help how the drug performs. Let's toss that into the clip...


        This mentality portrayed on this commercial captures the essence of my problem with drug treatment for any serious disease but, especially, Type 2 Diabetes. People want a solution to a complex problem (T2D) but gloss over the issue of lifestyle with words like, "I eat 'healthy' and I get plenty of exercise at work!"...

        If lifestyle has been PROVEN to injure, aren't you forcing your entire medical team of doctors/specialists, armed with their drugs, to swim against the tide (T2D), unless you improve your lifestyle for the better?

        Think about it. Suppose your patient takes your "Glucagon-like peptide-1 analogues" and she gets better...
        How do you know if it was the "analogues" or the spinach salad she started eating because Dr. Oz said this is the best meal you can eat to improve your health?

        If lifestyle can injure, the key to healing the injury is to reverse your freaking lifestyle!

        ...It worked for me. It will work for you...
        ...You don't get something for nothing...
        ...What you put in, is what you get out...
        ...You get what you pay for...

        This is how the world works, is it, not?
        So, why in $%#@ do you think it's any different for Type 2 Diabetes?