• 2 months ago

    Long-term use of Diphenhydramine

    I've had insomnia for years now and end up taking 25mg of Diphenhydramine (the active ingredient in Benadryl, ZzzQuil, and other over-the-counter sleep aids) most nights. I don't have any real side effects, and nothing I've read about the drug indicates that this kind of use would cause health problems, but I do wonder whether it might be affecting my liver--or my health in other ways. Does anyone know?

Responses

  • 2 months ago

    RE: Long-term use of Diphenhydramine

    Bit surprising to me that you have no side effects . When I tried these classes of drugs it caused a grogginess during the day that took hours to wear off. Worse than the insomnia.

    I'm not aware of any long term studies proving the safety of these drugs for chronic insomnia. I do know they're not recommended by the AASM.

    If you're concerned about this, a good start would be a checkup with your doc, to either treat medically or rule out the possibility of an underlying medical condition causing your insomnia.

    If it were me I'd try a tapering strategy under the supervision of a doc, then strengthen my sleep system to the point where no drugs are needed. Sleep in reality is as natural, normal, and needed as breathing -- and we don't usually have to take drugs to breathe.
      • 2 months ago
        Good advice. I do get the grogginess during the day after several nights of taking Benadryl. And then no sleep the next night, (like now). Sleep is Good.
  • 2 months ago

    RE: Long-term use of Diphenhydramine

    My Doctor said I could take up to 50mg of Benadryl per night to help with itching and sleep. Chronic pain and meds cause severe insomnia for me.

    Check on the Web for Cranberry extract liquid caps, & Milk Thistle Capsules.
    They both come in a 315 MG per serving or so. I have been on strong pain meds for too long. My Doc has check my blood to see the tocin levels my liver, & kidneys. Told him what I was doing and he said to keep it up. Liver, & Kidns doing well.
  • 1 month ago

    RE: Long-term use of Diphenhydramine

    I have recently Benadryl and Ambien are linked to Alzheimer's Dementia. Well, at least a higher incidence of people with Dementia having a history of taking them. Maybe research it a little more?